Core Properties and Chemical Structure Chemical Attribute: It belongs to the dihydroflavone class of flavonoids, with a molecular formula of C₁₆H₁₄O₆. It has a phenolic hydroxyl structure with antioxidant activity, which is the basis for its various biological effects.
Solubility: It has poor water solubility on its own, but its solubility can be improved after processing (e.g., combining with glycosides to form hesperidin), making it more easily absorbed and utilized by the human body.
Main Efficacy and Effects (Based on Research and Traditional Applications)
Powerful Antioxidant and Anti-Inflammatory Effects
Hesperetin can scavenge free radicals in the body, inhibit lipid peroxidation, and reduce oxidative stress-induced damage to cells, thereby delaying cell aging and protecting organs such as the cardiovascular system and liver. It can inhibit the release of inflammatory factors (such as TNF-α, IL-6), alleviate chronic inflammatory reactions, and has potential auxiliary relieving effects on arthritis, intestinal inflammation, etc.
Cardiovascular Protection
Auxiliary regulation of blood lipids: Studies have shown that hesperetin may reduce total cholesterol and triglyceride levels in the blood, while increasing high-density lipoprotein ("good cholesterol"), reducing the risk of atherosclerosis.
Improvement of vascular function: By relaxing vascular smooth muscles and promoting vasodilation, it helps maintain normal blood pressure and protects the health of vascular endothelial cells.
Metabolic Regulation and Blood Glucose Control
It may enhance insulin sensitivity, promote glucose uptake, and assist in regulating blood glucose levels, which is beneficial for individuals with pre-diabetes or mild diabetes.
It inhibits adipocyte differentiation, reduces fat accumulation, and may play an auxiliary role in weight management.
Sources and Acquisition Methods Natural Sources: It is mainly present in the peels (with the highest content), pulps, and juices of citrus fruits, among which orange peels and tangerine peels are particularly rich in hesperetin.
Extraction and Supplementation:
In daily life, it can be ingested by eating citrus fruits (eating a small amount with the peel or drinking freshly squeezed juice), but the content is relatively low.
Industrially, hesperetin can be extracted from citrus peels and made into health products (such as capsules, tablets) or
Food Additives, used to enhance the antioxidant efficacy of products. Notably,
Hesperetin extract nutraceutical grade and
Pure hesperetin powder supplement are widely used in the nutraceutical industry for their high purity and bioavailability.
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