Andrographolide is a diterpene lactone compound extracted from the plant Andrographis paniculata of the Acanthaceae family. It is one of the main active ingredients of the traditional Chinese medicine Andrographis paniculata. It appears as white square prisms or flaky crystals, odorless and bitter. Andrographolide dissolves in boiling ethanol, slightly soluble in methanol or ethanol, very slightly soluble in chloroform, and almost insoluble in water or ether. It has the effects of removing heat and detoxification, anti-inflammatory and analgesic. It has special effects on bacterial and viral upper respiratory tract infections and dysentery, and is known as a natural antibiotic drug.
The Effect of Andrographolide
1. Anti-pathogenic microbial effect
In vitro experiments show that Andrographis paniculata has a certain anti-HIV effect.
2. Antipyretic effect
Andrographolide has different degrees of antipyretic effect on endotoxin fever in rabbits, fever caused by pneumococcus or hemolytic streptococci.
3. Anti-inflammatory effect
Andrographis paniculata A, B, C, and D all have different degrees of anti-inflammatory effects. 1g/kg oral administration can inhibit the increase in the permeability of mouse skin or peritoneal capillaries caused by xylene or acetic acid, and reduce the amount of acute exudate caused by croton oil in Selye granuloma, but has no significant effect on the proliferation of granulation tissue.
4. Effect on the body's immune function
It has been reported that Andrographis paniculata may have an effect on certain aspects of cellular immunity.
5 Anti-fertility effect
Andrographis paniculata has a significant effect of aborting pregnancy.
6. Choleretic and hepatoprotective effect
Andrographis paniculata has a choleretic effect on rats, and can increase the liver weight of rats and shorten the sleep time caused by cyclohexylbarbital sodium. It has been reported that the methanol extract of Andrographis paniculata is toxic and can promote the death of rats with liver damage.
7. Anti-tumor effect
Dehydroandrographolide succinate half ester has a certain inhibitory effect on W256 transplanted tumors.
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